U.V irradiation of synthetic DNA sequence in the presence of Co 2+
| Author(s) | : | 1Chandra Sekhar Rao, Nagalakshmi |
| Institution | : | Associate Professor H&S Department, Vardhaman College Of Engineering, Kacharam,Shamshabad, Hyderabad |
| Published In | : | Vol. 3, Issue 11 — November 2016 |
| Page No. | : | 85-89 |
| Domain | : | Engineering |
| Type | : | Research Paper |
| ISSN (Online) | : | 2348-4470 |
| ISSN (Print) | : | 2348-6406 |
M-DNA is a complex between DNA and cobalt (II), nickel (II) or zinc (II) that forms under alkaline conditions.It has been postulated that the imino proton of guanine or thymine is replaced by the metal cation in each base-pair. Thecomplex is thought to maintain a double-helical structure similar to B-DNA but has unusual properties. M-DNA acts asan electron conductor making it a potential candidate for future nanotechnology applications. Crosslinks induced by UVradiation also formed at a faster rate for the Co2+, forms of M-DNA compared to B-DNA. In this case crosslinkingoccurred in all DNA but was more prominent in A-T base-pairs.
1Chandra Sekhar Rao, Nagalakshmi, “U.V irradiation of synthetic DNA sequence in the presence of Co 2+”, International Journal of Advance Engineering and Research Development (IJAERD), Vol. 3, Issue 11, pp. 85-89, November 2016.
